May 2019
In this Issue
Critical Limb Ischemia
Clinical trial updates, technical tips, and collaborative approaches to care.
Guest Chief Medical Editors’ Page
Surveying the CLI Landscape
By Jos C. van den Berg, MD, PhD, and Jihad A. Mustapha, MD
COVER STORIES
CLI Trial Update: Where Do We Stand on Data Collection?
An overview of the current evidence and perspectives on what data are still needed.
By Bram Fioole, MD, PhD; Joost A. Bekken, MD; and Hence Verhagen, MD, PhD

CLI Trial Update: The CRITISCH Registry
Investigators provide an overview of registry data examining various treatment options for patients with CLI.
By Theodosios Bisdas, MD; Giovanni Torsello, MD; and Konstantinos Stavroulakis, MD
CLI Trial Update: The BEST-CLI Trial
A summary of the trial’s design and goals and an update on its progress to date.
By Matthew Menard, MD; Alik Farber, MD; and Kenneth Rosenfield, MD
CLI Management and Outpatient Center Considerations
Factors to consider in providing specialized care for this patient population.
By Fadi Saab, MD; Bret N. Wiechmann, MD; and Christopher LeSar, MD
Ask the Experts: What Is Your Top Tip on How to Safely and Efficiently Cross a Lower Extremity CTO?
Experts discuss their access approaches to and techniques for crossing chronic total occlusions.
With John A. Phillips, MD; Saher Sabri, MD, FSIR; Ramon L. Varcoe, MBBS, MS, FRACS, PhD; Sabine Steiner, MD; and Osamu Iida, MD
Optimal Medical Therapy for CLI: Recent Advances and the Need for More Data
A conversation with the President of the Society for Vascular Medicine on current best practices for medical therapy in this challenging population.
With Heather L. Gornik, MD
CLI Revascularization Advice From a Surgeon Who Performs Distal Bypass
Decisions regarding type of therapy and insights from a surgeon to endovascular specialists.
By Richard F. Neville, MD, FACS
Ask the Experts: What Are Your Surveillance Protocols After Below-the-Knee Interventions, and What Determines the Need for Reintervention?
Experts discuss their approach to postprocedural management.
With John H. Rundback, MD; Marianne Brodmann, MD; Misaki Kiguchi, MD, MBA, MSc, RPVI; and Thomas Zeller, MD, PhD

Critical Limb Ischemia: A Threat to Life and Limb
CLI is an underdiagnosed and undertreated deadly disease that requires proper diagnostic imaging and increased awareness.
By Jihad A. Mustapha, MD; Barry T. Katzen, MD; Richard F. Neville, MD, FACS; Robert A. Lookstein, MD; Thomas Zeller, MD, PhD; Larry E. Miller, PhD; Vickie R. Driver, DPM; and Michael R. Jaff, DO
CONTINUING COVERAGE: PACLITAXEL IN PAD

FDA Paclitaxel Safety Panel Preview
An interview with FDA CDRH representatives discussing the upcoming advisory panel meeting to review concerns and current data on paclitaxel-eluting device use.
By Kenneth Cavanaugh, PhD; and Misti Malone, PhD
ONLINE EXCLUSIVE

Mentors and Protégés: Conversations on Career and Craft With Riad Salem, MD
Alexander Logsdon, DO, and Adam Sucher, DO, talk with Dr. Salem about balancing research and clinical responsibilities, his journey in establishing Y-90 as a standard of care, and his advice to aspiring clinical researchers, among other topics.
FEATURED TECHNOLOGY
Sponsored by Silk Road Medical
The Shifting Paradigm in Carotid Revascularization: TCAR in Real-World Practice
By Marc Schermerhorn, MD; and Patric Liang, MD; with an accompaniment by Bernardino C. Branco Rocha, MD
Case Report: Successful Recanalization of a Totally Occluded Anterior Tibial Artery With Excimer Laser
By Kan Karl Zhang, MD, MBA
MEDICAL AFFAIRS CORNER
Sponsored by MedtronicPeripheral Artery Disease Below the Knee: Unique Challenges and Algorithmic Solutions
By Peter P. Monteleone, MD
DEPARTMENTS
Innovations
An Interview With Tilo Kölbel, MD, PhD
Dr. Kölbel shares his protocols for false lumen occlusion in TEVAR, updates on stroke and spinal cord ischemia prevention, and more.