RFPi Receives NIH Grant to Develop Novel Evaluation Tool for Asymptomatic Patients at Risk for PAD


October 2, 2019—RFPi Inc. announced it has received a grant from the US National Institutes of Health (NIH) to develop a novel, imaging-based medical device that health care providers could use to test asymptomatic patients at risk for peripheral artery disease (PAD). The $1.48 million grant from the NIH’s National Heart, Lung, and Blood Institute will help RFPi scientists develop a prototype device that provides a more efficient way to detect PAD.

RFPi invented this technology in 2010 at East Carolina University in Greenville, North Carolina, with a team of cardiovascular medicine, optical physics, and engineering experts.

According to the company, RFPi is a midstage startup company based in Greenville that is developing medical imaging technologies using the company's multispectral physiologic visualization (MSPV) system. MSPV uses low-energy lasers, high-speed imaging cameras, and analyses and algorithms to deliver real-time visualization and quantification of blood flow distribution (flow and perfusion), without the need for injections, radiation, or direct patient contact.

The company anticipates the deployment of new technologies that improve surgical and clinical outcomes, enhance patient care, and reduce health care costs. In December 2018, RFPi received FDA 510(k) clearance to market the iCertainty blood flow and perfusion imaging medical device for use by surgeons in open surgery.

With this NIH grant, RFPi’s scientists will implement the design of a technology that measures a patient’s blood pressure in both upper and lower extremities simultaneously, using no-risk, noninvasive, no-contact, and nonionizing imaging that captures data in 10 seconds and displays actual results in real time. RFPi then will evaluate the prototype in a clinical study conducted with the Division of Vascular Surgery at Brody School of Medicine at East Carolina University, and the Division of Vascular Surgery at the University of Rochester in Rochester, New York, New York.


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